Go to the Control Panel for the ActivPanel (Monitor).

Windows:

Click on the Windows Start button and choose All Programs or Programs. Then navigate to Tablet group and choose the Tablet option.

Select the Calibrate tab.

Mac:

Open System Preferences from the Apple menu or from the Applications folder. Then click on the Tablet icon.

Select the Calibrate tab.

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Click on the Calibrate button to activate the calibration screen.

Hold the pen as you normally do, and use the pen tip to click on the center of the cross-hairs in the upper-left corner.

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Then click on the center of the cross-hairs that are displayed in the lower-right corner.

Test the alignment and click OK to accept the calibration. Click Try Again to recalibrate.

The calibration screen will provide more detailed instructions.